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1+ hour, 13+ min ago  (744+ words) In a groundbreaking advancement in protein engineering, researchers have unveiled a versatile approach to precisely modify proteins and peptides utilizing the engineered asparaginyl ligase, Oa AEP1. This ultrafast transpeptidase transcends its canonical biological role, enabling an expansive repertoire of site-specific modifications…...

16+ hour, 37+ min ago  (372+ words) Schematic of MOLEXA reconstructing molecular structure from Coulomb explosion imaging data. Ion momentum patterns generated by intense X-ray pulses are analyzed by a generative AI model to infer molecular geometry and its uncertainty. Newswise " Researchers at the U. S. Department of Energy's…...

9+ min ago  (1033+ words) Bioengineer. org In the ever-evolving universe of drug discovery, the profound intricacies of natural products stand as a beacon of hope and challenge alike. These small molecules, derived from microorganisms, plants, and animals, possess a rich and diverse array of…...

57+ min ago  (1634+ words) A preprint version of the article is available at ar Xiv. Chandrasekhar, V. et al. COCONUT 2. 0: a comprehensive overhaul and curation of the collection of open natural products database. Nucleic Acids Res. 53, 634643 (2025). Newman, D. J. & Cragg, G. M. Natural products as sources of new drugs from…...

59+ min ago  (1315+ words) a Shows how the reaction is encoded by adding the moiety counts of the products and subtracting the substrates. b Shows how the complete reaction is decomposed into elementary steps, each encoded using specific moieties. Included in the moiety description…...

10+ hour, 44+ min ago  (144+ words) Yonhap News Agency Chula's Chemistry Metaverse Harnesses Gaming to Transform Science Education Unlike traditional laboratories, often constrained by cost, equipment shortages, and safety risks, the metaverse provides a risk-free environment where students can experiment freely without real-world consequences, reinforcing safety…...

3+ hour, 32+ min ago  (179+ words) | Newswise'Newswise One Day's Work in an Hour: A Versatile, Fast-scanning, X-ray Microscope Innovative, high-resolution X-ray microscopy system generates 3 D images 20 times faster than the previous system. This illustration shows multilayer Laue lenses within the microscope focusing incoming X-rays on the…...

1+ hour, 53+ min ago  (1052+ words) Alkenes are widely used functional groups in synthetic chemistry, important for producing polymers, detergents, agrochemicals and pharmaceuticals. When treated with electrophiles, alkenes typically undergo addition, not substitution, reactions1. As a consequence, the intuitive retrosynthetic disconnection to form a substituted alkene from…...

2+ hour, 31+ min ago  (481+ words) Dr. Donovan is a futurist and technology writer covering the quantum revolution. Where classical computers manipulate bits that are either on or off, quantum machines exploit superposition and entanglement to process information in ways that classical physics cannot. Dr. Donovan…...

2+ hour, 51+ min ago  (236+ words) A physicist and a materials scientist are Cornell's 2026 electees to the National Academy of Sciences (NAS), the academy announced April 28. The newly elected members are'Daniel Ralph, Ph. D. '93, the F. R. Newman Professor of Physics in the College of Arts and Sciences; and'Darrell…...