Enzyme Redesign Turns Photochemistry Into a Route to Chiral Phosphorus Compounds
A repurposed imine reductase uses photoexcited NADP+ to generate P-centred radicals and forge chiral carbon–phosphorus bonds with divergent stereocontrol. Chemists have long struggled to control the handedness of phosphorus-centred radicals, reactive intermediates that could unlock a valuable class of molecules but have stubbornly resisted stereocontrol Now a team writing in…