Fungal Lys1 Enzymes Show Conserved Folds but Divergent Catalytic Kinetics
A comparative study of fungal Lys1 enzymes revealed conserved structural folds alongside distinct catalytic rates, activation energies, and strong directional pH dependence. In a comparative study combining phylogenetic, biophysical, kinetic, and molecular dynamics analyses, researchers characterized the saccharopine dehydrogenase Lys1 (EC 1.5.1.7) across diverse fungal species, identifying shared structural architectures…