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News
One Amino Acid Decides Whether Mitochondria Keep Their Protein Machines
2+ hour, 9+ min ago (75+ words) Mitochondria are the power stations of the cell, but they are also among the most dependent organelles in biology. The vast majority of the roughly one thousand proteins that make up a working mitochondrion are manufactured outside the organelle, in…...
New AI Framework SCIGMA Unifies Spatial Multiomics Data With Built-In
2+ hour, 35+ min ago (674+ words) Spatial omics technologies have transformed biology by allowing scientists to measure gene expression, proteins, chromatin states and even metabolites directly within intact tissue sections, preserving the geographical context that single-cell methods discard....
Protein Assembly, Not Abundance, Explains Why Cells Behave So Differently
3+ hour, 15+ min ago (689+ words) For decades, biologists have treated protein abundance as the closest available proxy for what a cell is actually doing. Measure how much of each protein a cell produces, the reasoning went, and you have a reasonable snapshot of its functional…...
New Web Tool Lets Researchers Hand-Pick Cells Directly on Spatial Omics
3+ hour, 53+ min ago (573+ words) Spatial biology has been having its breakout decade. Technologies such as imaging mass cytometry, multiplexed immunofluorescence and other multiplexed imaging platforms now allow researchers to measure dozens of biomolecules simultaneously while keeping every cell locked in its original position within…...
Transfer Learning Reconstructs the Signaling Histories of Single Cells
4+ hour, 46+ min ago (704+ words) Every cell in the body carries a hidden biography. Long before a researcher harvests a tissue and sequences its contents, that cell has been bombarded by hormones, growth factors, cytokines and stress signals, and its current state is the accumulated…...
Stashed at the Speckle’s Edge: Hidden RNA Stockpile Splices in Sync as
5+ hour, 3+ min ago (98+ words) Deep inside the nucleus of every human cell, a quiet stockpile of genetic messages sits waiting for its moment. A new study published in Nature Cell Biology reveals that a large class of incompletely processed RNA molecules is not scattered…...
Duplicated Energy Genes Reveal How Fish Mitochondria Evolved After Genome
5+ hour, 28+ min ago (620+ words) Every heartbeat, every twitch of a fin, and every dividing cell in a fish embryo depends on a molecular machine so ancient that its origins trace back billions of years. Oxidative phosphorylation, or OXPHOS, is the process by which cells…...
Copper Supercharges Beta-Carboline Metal Complexes Against Aggressive
5+ hour, 55+ min ago (793+ words) Chemists have long known that threading a metal into an organic molecule can transform its biological personality, and a striking new demonstration of that principle has emerged from a team working on beta-carboline alkaloids....
Newly Discovered Trypsinogen Variants Drive Immune Responses in
6+ hour, 31+ min ago (654+ words) A team of researchers in China has uncovered a genetic clue that may help explain why some patients develop immunoglobulin G4-related disease, a chronic fibroinflammatory condition that can strike the pancreas, salivary glands, and other organs....
The human heart tries to regenerate after a heart attack — scientists are learning why the repair falls short
20+ hour, 46+ min ago (625+ words) The adult heart may be trying to repair itself after a heart attack—it just struggles to finish the job. For decades, the adult heart was treated as an organ with almost no ability to replace the muscle cells lost…...