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News
Aptamer-Guided CRISPR-Cas9 Delivery Could Make Cancer Genome Editing
1+ day, 8+ hour ago (55+ words) Gene editing has long promised a revolution in cancer medicine, yet the promise has remained stubbornly out of reach for one deceptively simple reason: getting the CRISPR-Cas9 machinery into tumor cells, and only tumor cells, is extraordinarily difficult. A new…...
Machine Learning Meets X-Rays to Reveal the Hidden Architecture of Pea
1+ day, 11+ hour ago (95+ words) Every seed is a masterpiece of biological engineering, a compact package in which molecular order and cellular design are woven together to protect and nourish a future plant. For scientists trying to understand how crops such as the yellow pea…...
New AI Framework SCIGMA Unifies Spatial Multiomics Data With Built-In
1+ day, 14+ hour ago (674+ words) Spatial omics technologies have transformed biology by allowing scientists to measure gene expression, proteins, chromatin states and even metabolites directly within intact tissue sections, preserving the geographical context that single-cell methods discard....
Protein Assembly, Not Abundance, Explains Why Cells Behave So Differently
1+ day, 15+ hour ago (689+ words) For decades, biologists have treated protein abundance as the closest available proxy for what a cell is actually doing. Measure how much of each protein a cell produces, the reasoning went, and you have a reasonable snapshot of its functional…...
DNA-Binding Protein Fusions Supercharge PAM-Flexible, High-Precision Base
1+ day, 15+ hour ago (77+ words) Scientists have unveiled a significantly upgraded CRISPR base editing platform that combines near-unrestricted DNA targeting with pinpoint accuracy and markedly higher efficiency, potentially transforming efforts to correct disease-causing mutations and engineer improved crops. In a study published in Advanced Science,…...
New Web Tool Lets Researchers Hand-Pick Cells Directly on Spatial Omics
1+ day, 15+ hour ago (573+ words) Spatial biology has been having its breakout decade. Technologies such as imaging mass cytometry, multiplexed immunofluorescence and other multiplexed imaging platforms now allow researchers to measure dozens of biomolecules simultaneously while keeping every cell locked in its original position within…...
Transfer Learning Reconstructs the Signaling Histories of Single Cells
1+ day, 16+ hour ago (704+ words) Every cell in the body carries a hidden biography. Long before a researcher harvests a tissue and sequences its contents, that cell has been bombarded by hormones, growth factors, cytokines and stress signals, and its current state is the accumulated…...
Cryo-EM Reveals How Cas12a Uses a DNA Guide to Hunt RNA Targets
1+ day, 19+ hour ago (741+ words) The CRISPR world has long been organized around a simple division of labor: some Cas enzymes are steered by RNA guides to cut DNA, while others are loaded with DNA guides to find RNA....
Dual-State Structures Reveal How Drugs Switch the Immune Receptor GPR84
1+ day, 19+ hour ago (69+ words) A receptor long viewed as one of the more enigmatic members of the lipid-sensing G protein-coupled receptor family is now coming into sharp molecular focus. New research published in Experimental & Molecular Medicine describes how structural snapshots of GPR84, captured in distinct…...
Scientists Chart a Common Roadmap to Bring Senescence Medicine Into the
1+ day, 20+ hour ago (641+ words) In May 2026, the historic university city of Coimbra, Portugal, played host to a gathering that many in the aging research community hope will be remembered as a turning point....