4+ hour, 31+ min ago   (506+ words) Foundation models have delivered breakthroughs in fields such as protein structure prediction, but single-cell biology presents different challenges. This article explores why scale alone is not enough and what kinds of AI may better support drug discovery. The wide variety…...

2+ week, 4+ day ago   (1098+ words) Drug developers have generated decades of toxicology data and insights, but much of it remains underused. Laura Lotfi of Charles River Laboratories discusses how Virtual Control Groups and AI could help put that information to work. Safety assessment is a…...

1+ mon, 1+ week ago   (1229+ words) Non-animal methods are already used throughout early drug discovery, yet animal testing continues to dominate regulatory safety assessment. Recent initiatives suggest change is coming, but significant scientific and practical challenges remain. Governments and regulatory bodies across the UK, US, EU…...

1+ mon, 2+ week ago   (184+ words) As drug developers pursue increasingly complex therapies, traditional bioanalytical approaches are being put to the test. How is the field adapting to meet these new demands? As pharmaceutical research and development has evolved, however, the scope and demands placed on…...

3+ mon, 4+ day ago   (653+ words) Scientists have discovered a factor that could modify the way in which new medicines are developed, after discovering that subtle chemical changes to proteins can determine whether they respond to drugs. The research, led by Scripps Research, shows that post-translational…...

3+ mon, 6+ day ago   (425+ words) “We discovered a novel form of transformation from 2-azidoacrylate esters to diazo compounds via the formation of a phosphazide intermediate and subsequent Michael addition,” says Professor Yoshida. The innovation lies in adapting a classic reaction. The Michael addition typically involves…...

3+ mon, 2+ week ago   (342+ words) Researchers at the University of Wisconsin–Madison have reported a new approach to forming carbon–nitrogen bonds, a critical step in the synthesis of amines widely used in pharmaceuticals, agrochemicals and polymers. Scientists at the University of Wisconsin–Madison have…...

4+ mon, 2+ week ago   (1273+ words) Proteins are often studied as static structures, yet they behave dynamically in living systems. Tiffanwy Klippel-Cooper of OmnigeniQ explains how physics-based modelling could help researchers better understand drug targets. A new approach emerging from Australian start-up OmnigeniQ aims to change…...

4+ mon, 3+ week ago   (754+ words) Scientists at the University of Cambridge have developed a light-powered method to modify complex drug molecules without toxic chemicals, enabling faster, cleaner and more efficient drug development. Scientists at University of Cambridge have developed a new technique that uses light…...

6+ mon, 1+ week ago   (552+ words) Researchers have developed a new class of stable boron compounds that could make it easier to improve existing medicines, allowing developers to fine-tune effectiveness without rebuilding drugs from scratch. Researchers at the University of Gothenburg are simplifying drug development by…...