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CATCHing off-target drugs - Nature Methods
2+ hour, 39+ min ago (75+ words) Nature Methods (2026)Cite this article Ye and colleagues imaged and analyzed organ distribution of clickable derivatives of two covalently binding cancer drugs, afatinib and ibrutinib, with known but poorly understood side effects. By incorporating histology of identified off-target organs, the…...
Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres - Nature Synthesis
6+ hour, 48+ min ago (1196+ words) Nature Synthesis (2026)Cite this article aDefined as logP at pH 7.4; determined by high-performance liquid chromatography (HPLC) analysis. bDefined as metabolic half-life. cDefined as microsome intrinsic clearance. dDefined as hepatic intrinsic clearance. eDetermined at 60min in the presence of human liver microsomes…...
Contra-electronegativity transmetallation unlocks alkene carbomagnesiation to access quaternary stereocentres - Nature Chemistry
7+ hour, 4+ min ago (978+ words) Nature Chemistry (2026)Cite this article Grignard, V. Some new organometallic combinations of magnesium and their application to the synthesis of alcohols and hydrocarbons. C. R. Acad. Sci. 130, 13221325 (1900). Silverman, G. S. & Rakita, P. E. (eds) Handbook of Grignard Reagents (Marcel Dekker, 1996). Knappke, C. E. I. & Wangelin, A. J. V. 35 years of palladium-catalyzed cross-coupling with…...
Cation–polymer interactions drive water expulsion and deswelling in n-type ladder organic mixed conductors - Nature Materials
7+ hour, 29+ min ago (1585+ words) Nature Materials (2026)Cite this article BBL was synthesized according to a previously reported procedure in ref. 43. NaCl (99.0%), MMACl (98%), TMACl (99.0%), methanesulfonic acid (MSA, 99.0%) and HCl (37% in water) were purchased from Sigma-Aldrich. DMACl (98.0%) and TMACl (98.0%) were obtained from Merck, and NH4Cl (99.5%) was obtained…...
Electrolyte design curbs side reactions - Nature Energy
8+ hour, 23+ min ago (138+ words) Nature Energy (2026)Cite this article Aqueous zinc-ion batteries offer strong potential for high-energy grid storage but rely on acidic conditions that cause severe zinc corrosion. Now, a hybrid eutectic aqueous'organic electrolyte is reported that suppresses side reactions and enables highly…...
Recent advances in coacervate protocells from passive catalysts to chemically programmable systems - Communications Chemistry
16+ hour, 18+ min ago (1625+ words) The design of living-system readouts carries particular significance for bioengineering when a pre-concentrated reaction inside the coacervate serves as the bridge, and the emitted message is one that native pathways already interpret. This bridge typically relies on small-molecule effectors like…...
Crystalline nitrogen chain radical anions - Nature Chemistry
20+ hour, 46+ min ago (1785+ words) Nature Chemistry (2026)Cite this article Greenwood, N. N. & Earnshaw, A. Chemistry of the Elements (Elsevier, 2012). Klap'tke, T. M. Chemistry of High-Energy Materials (De Gruyter, 2022). O'Sullivan, O. T. & Zdilla, M. J. Properties and promise of catenated nitrogen systems as high-energy-density materials. Chem. Rev. 120, 56825744 (2020). Heelis, R. A. & Maute, A. Challenges to understanding the Earth's…...
Deep learning for asymmetric catalysis - Nature Computational Science
1+ day, 2+ hour ago (177+ words) A recent study develops a model for predicting stereoselectivity and absolute configurations in asymmetric hydrogenation of olefins. Brown, J. M. & Deeth, R. J. Angew. Chem. Int. Ed. 48, 44764479 (2009). Peng, Q., Duarte, F. & Paton, R. S. Chem. Soc. Rev. 45, 60936107 (2016). Pinus, S., Genzling, J., Burai-Patrascu, M. & Moitessier, N. Nat. Catal. 7, 12721287 (2024). Guan, Y., Ingman, V. M., Rooks, B. J. & Wheeler, S. E. J. Chem....
A federated graph learning method to realize multi-party collaboration for molecular discovery - Nature Machine Intelligence
1+ day, 10+ hour ago (1338+ words) LeCun, Y., Bengio, Y. & Hinton, G. Deep learning. Nature 521, 436444 (2015). Abramson, J. et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature 630, 493500 (2024). Stokes, J. M. et al. A deep learning approach to antibiotic discovery. Cell 180, 688702.e13 (2020). Hartono, N. T. P. et al. How machine learning can help select capping layers…...
Monitoring organic contaminants in aquatic systems with liquid chromatography–mass spectrometry - Nature Reviews Earth & Environment
1+ day, 13+ hour ago (53+ words) Nature Reviews Earth & Environment (2026)Cite this article State Key Laboratory of Advanced Environmental Technology, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China University of Chinese Academy of Sciences, Beijing, China Correspondence to Zixiao Wu. Version of record: 10 February…...