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News
DartUniFrac Brings Megascale Computing to Microbiome Diversity Analysis
59+ min ago (512+ words) Researchers have introduced DartUniFrac, a new software tool designed to carry out UniFrac-based microbiome comparisons at a scale that was previously impractical....
Engineered Bacterial Teams Turn Sunlight and CO2 Into 1-Butanol
1+ hour, 21+ min ago (350+ words) Scientists at Uppsala University have taken a significant step toward a long-sought goal in industrial biotechnology: using sunlight and carbon dioxide to feed engineered microbes that churn out valuable chemicals. In a study published in Applied Microbiology and Biotechnology, Stamatina…...
Protein Assembly, Not Abundance, Explains Why Cells Behave So Differently
3+ hour, 15+ min ago (689+ words) For decades, biologists have treated protein abundance as the closest available proxy for what a cell is actually doing. Measure how much of each protein a cell produces, the reasoning went, and you have a reasonable snapshot of its functional…...
Stashed at the Speckle’s Edge: Hidden RNA Stockpile Splices in Sync as
5+ hour, 4+ min ago (98+ words) Deep inside the nucleus of every human cell, a quiet stockpile of genetic messages sits waiting for its moment. A new study published in Nature Cell Biology reveals that a large class of incompletely processed RNA molecules is not scattered…...
Chemists Deploy Palladium to Switch Off and On a Key Amino Acid in Living
5+ hour, 46+ min ago (703+ words) Phenylalanine rarely gets top billing in discussions of molecular biology, yet this unassuming aromatic amino acid quietly underpins some of the most fundamental processes in the cell....
Copper Supercharges Beta-Carboline Metal Complexes Against Aggressive
5+ hour, 55+ min ago (793+ words) Chemists have long known that threading a metal into an organic molecule can transform its biological personality, and a striking new demonstration of that principle has emerged from a team working on beta-carboline alkaloids....
Dual-State Structures Reveal How Drugs Switch the Immune Receptor GPR84
7+ hour, 30+ min ago (69+ words) A receptor long viewed as one of the more enigmatic members of the lipid-sensing G protein-coupled receptor family is now coming into sharp molecular focus. New research published in Experimental & Molecular Medicine describes how structural snapshots of GPR84, captured in distinct…...
Newly Identified GPCR-Like Protein TM184C Controls Cellular Exchange and
8+ hour, 37+ min ago (850+ words) A protein called TM184C has emerged as an unexpected player in two of the most fundamental processes in cellular life: the movement of materials between cells and the controlled recycling of a cell’s own internal components....
Chemists forge chiral piperidine mimics in a single asymmetric leap
17+ hour, 57+ min ago (904+ words) Medicinal chemists have long chased a deceptively simple goal: build drug candidates that are less flat, more three-dimensional, and more likely to succeed in the clinic....
Ufd1 Unfolds Ubiquitin Without ATP to Kick-Start Cdc48/p97 Waste Disposal
17+ hour, 57+ min ago (57+ words) Inside every cell, a molecular machine called Cdc48—known as p97 or VCP in humans—works around the clock to drag damaged, mislocated, or otherwise doomed proteins out of membranes and protein complexes so they can be shredded by the proteasome. For…...