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News
New computational tool reads hidden RNA cleavage signals in health and
28+ min ago (747+ words) For years, biologists catalogued small non-coding RNAs by counting how many of each type appeared in a sequencing run. That approach treated tiny RNA molecules as a census problem, and it worked well enough for microRNAs, the classical regulators of…...
DartUniFrac Brings Megascale Computing to Microbiome Diversity Analysis
59+ min ago (512+ words) Researchers have introduced DartUniFrac, a new software tool designed to carry out UniFrac-based microbiome comparisons at a scale that was previously impractical....
AI Uncovers Hidden Human Protein That Builds Bridges Between Cells
1+ hour, 13+ min ago (679+ words) For most of modern biology, the hunt for new human proteins has followed a familiar path: read the genetic sequence, predict where genes begin and end, and work outward from there. That strategy has served science remarkably well, delivering the…...
PROTACs Move From Lab Concept to Clinical Reality in Targeted Protein
1+ hour, 57+ min ago (746+ words) A sweeping new review published in Discover Chemistry charts the remarkable rise of proteolysis-targeting chimeras, better known as PROTACs, from a bold theoretical idea to one of the most closely watched platforms in modern drug discovery. Written by Sandip G....
New Web Tool Lets Researchers Hand-Pick Cells Directly on Spatial Omics
3+ hour, 55+ min ago (573+ words) Spatial biology has been having its breakout decade. Technologies such as imaging mass cytometry, multiplexed immunofluorescence and other multiplexed imaging platforms now allow researchers to measure dozens of biomolecules simultaneously while keeping every cell locked in its original position within…...
Phosphorus-Powered Pyrazoles Show Potent Antimicrobial Activity Against E.
5+ hour, 3+ min ago (739+ words) Chemists in Tunisia have unveiled a new family of phosphorus-containing pyrazole molecules that show striking antibacterial activity, particularly against the Gram-negative pathogen Escherichia coli....
Stashed at the Speckle’s Edge: Hidden RNA Stockpile Splices in Sync as
5+ hour, 5+ min ago (98+ words) Deep inside the nucleus of every human cell, a quiet stockpile of genetic messages sits waiting for its moment. A new study published in Nature Cell Biology reveals that a large class of incompletely processed RNA molecules is not scattered…...
Chemists Deploy Palladium to Switch Off and On a Key Amino Acid in Living
5+ hour, 47+ min ago (703+ words) Phenylalanine rarely gets top billing in discussions of molecular biology, yet this unassuming aromatic amino acid quietly underpins some of the most fundamental processes in the cell....
Copper Supercharges Beta-Carboline Metal Complexes Against Aggressive
5+ hour, 56+ min ago (793+ words) Chemists have long known that threading a metal into an organic molecule can transform its biological personality, and a striking new demonstration of that principle has emerged from a team working on beta-carboline alkaloids....
Complement Emerges as Central Player and Drug Target in Neurological
7+ hour, 23+ min ago (688+ words) The complement system, a sprawling network of plasma and membrane-bound proteins long regarded as little more than a first-response killing machine against microbes, is now recognized as one of the most consequential players in neurology. A comprehensive new review published…...