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Chemists forge chiral piperidine mimics in a single asymmetric leap
17+ hour, 57+ min ago (904+ words) Medicinal chemists have long chased a deceptively simple goal: build drug candidates that are less flat, more three-dimensional, and more likely to succeed in the clinic....
OrgAIcat predicts enantioselectivity in organocatalysis using literature data and rapidly optimizes reactions
4+ day, 3+ hour ago (1102+ words) Published chemical literature has accumulated a wealth of reaction data, but this data comes from diverse sources, is unevenly distributed, and is clearly biased towards highly selective "successful experiments." Can such literature data be used for reliable machine learning modeling…...
Evolving faster proximity chemistry - Nature Chemical Biology
5+ day, 13+ hour ago (204+ words) Nature Chemical Biology (2026) Cite this article Chen, Y., Chen, Y. & Qin, W. Chem. Asian J. 20, e202500118 (2025). Westberg, M., Bregnhøj, M., Etzerodt, M. & Ogilby, P. R. J. Phys. Chem. B 121, 9366–9371 (2017). Hananya, N., Ye, X., Koren, S. & Muir, T. W. Proc. Natl Acad. Sci. USA 120, e2219339120 (2023). Lam, S. S. et al....
Mild metal-free method enables direct alpha-heteroarylation of amides and
1+ week, 6+ day ago (879+ words) Zinc Powder, Room Temperature, No Palladium: Chemists Awaken a 130-Year-Old Reaction to Build Drug Molecules Every year the pharmaceutical industry fabricates medicines whose molecular backbones share one deceptively simple feature: a carbon atom bearing a three-dimensional substituent stitched directly onto…...
Microwave Chemistry Yields Promising Spiro-Benzothiazole Drug Leads in 20
2+ week, 19+ hour ago (903+ words) A simple mineral catalyst and microwave energy have helped researchers produce a collection of complex drug-like molecules in minutes, while reducing the time required for a conventional synthesis from hours to a fraction of one hour....
Scientists synthesize Z-allylamines using masked alkenyl anions from
2+ week, 1+ day ago (713+ words) Chemists have reported a new way to build stereodefined allylamines, a class of molecules that sits at the intersection of drug discovery, agrochemistry, organic synthesis and advanced materials....
Ligand-Guided Radical Orientation Enables Asymmetric Cyanation of
2+ week, 4+ day ago (623+ words) A new copper-catalysed reaction could give chemists a powerful way to create chiral molecules from some of the most difficult intermediates in organic chemistry: highly reactive, unstabilized alkyl radicals....
Catalysts Enable Asymmetric Carbonyl–Ene Reactions Between Unactivated
2+ week, 5+ day ago (56+ words) A reaction long regarded as one of synthetic chemistry’s most stubborn challenges has moved closer to practical use. In a study published in Nature Catalysis, J.A.A. Grimm, L. Shi, N. Tsuji and colleagues report a catalytic asymmetric intermolecular carbonyl–ene-type…...
New method synthesizes dialkyl ethers through homolytic heteroatom
3+ week, 2+ day ago (643+ words) substitution Bioengineer.org...
Scientists Develop Programmable Method to Rearrange Carbon–Nitrogen Bonds
3+ week, 5+ day ago (601+ words) Tertiary amines are among the most common structural features in biologically active molecules, appearing in medicines, natural products and chemical probes that interact with receptors, enzymes and transport proteins....