Chemists report a scalable multistep synthesis of indole–benzimidazole–piperazine carboxamide hybrids, optimized bond by bond and computationally profiled without claims of biological activity.
A DFT-based mini-review identifies tungsten-modified graphitic carbon nitride, with an adsorption energy of -3.104 eV, as the strongest computational candidate for capturing and sensing toxic hydrogen cyanide.
Researchers at The University of Osaka have developed a rhodium-catalysed reaction that inserts a single carbon atom into carbon–carbon σ-bonds of biphenylenes, forming four new C–C bonds at a spiro centre and enabling homo- and cross-spirofusion of complex…
Conceptual illustration of carbon-atom transfer for spirofusion. A single carbon atom supplied by PINC serves as a connecting point to join two planar molecules into a three-dimensional spirocyclic framework through rhodium-catalyzed C–C bond cleavage. Mamoru Tobisu and Hayato Fujimoto Mamoru…
Nature Synthesis (2026) Cite this article The data supporting the findings of this study are available in the article and its Supplementary Information. The deposition number for 3d is CCDC-2382493 and for 12b is CCDC-2382494. Liu, F.-Z. et al. Out-of-equilibrium confinement catalysis mediated by compressive force.
For OH + toluene, the OH addition mainly takes place in ortho position with branching ratios ortho / meta / para / ipso = 59 - 70% / 5% / 5 - 14% / 7 - 15% based on theoretical calculations3,4. The lesser H-abstraction on the side chain amounts to 7 - 12%3,4. First steps of the OH radical-initiated oxidation of toluene…
Source: Based on © Joshua K Mitchell et al and © Max Dietel et al After independently uncovering new synthetic pathways for generating substituted alkenes, two researchers were introduced by a journal editor who spotted similarities between papers they had rejected Source:…
Researchers at the University of Illinois Urbana-Champaign have reported a breakthrough in nickel catalysis that harnesses a rare oxidation state of nickel that has proved challenging to control yet is highly valued for its potential to facilitate important chemical reactions.
Nature Chemistry (2026) Cite this article a, Bonding models of Schrock alkylidynes and Fischer carbynes, types of Fischer carbyne and associated resonance forms. b, Potential electromers of the carbyne motif. c, Conversion of a diazo-phosphorus ylide to a carbyne equivalent with…
Molecular catalysts in solution: transition-metal complexes, organocatalysts and asymmetric catalysis for making chiral molecules.
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