A new Frontiers in Chemistry review surveys ruthenium-catalyzed C–H activation, annulation, and hydrogen-borrowing strategies for building bioactive heterocycles. Ruthenium Catalysis Emerges as a Versatile Route to Bioactive Heterocycles
Researchers optimized a mild food-grade extraction that recovers 8.22 milligrams of rutin per gram from discarded Piennolo tomato leaves and showed in ex vivo porcine skin that the flavonol accumulates in the epidermis and dermis with limited transdermal passage.
A validated HPLC method has captured the first simultaneous pharmacokinetic profiles of betulinic and ursolic acids absorbed from grey mangrove extract in female Wistar rats. Mangrove extract delivers triterpenes fast in rat pharmacokinetic first Subject of Research: Pharmacokinetic profiling of…
Nature (2026) Cite this article We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final…
Chemists and enzymologists have long relied on mechanism-guided design to create new enzymatic reactions, but a team writing in Nature Catalysis reports a complementary strategy: systematically screening enzyme–photocatalyst pairings to let unexpected reactivity surface on its own. Among the…
Milder conditions, less energy consumption and waste The weak spot of enzyme biocatalysis is the low stability of some enzymes. "Since the enzyme often has to be replaced in such cases -- which is expensive -- it is extremely important to increase…
Laboratory screening of compounds isolated from Jatropha curcas roots identified curcusones B and C as potent, slow-acting inhibitors of Plasmodium falciparum that preferentially target late-ring and early-trophozoite stages, though their selectivity over mammalian cells remains modest. News Source: Ophelia Keating.
The study, conducted by Fatemeh Abolmashadi, Mahdi Moridi Farimani, and Gholamreza Farnoosh, did not involve new laboratory experiments with the compounds themselves. Instead, the researchers reanalyzed two publicly available mouse microarray datasets, GSE150218 and GSE190056, to identify differentially expressed genes, hub genes,…
A multivariate study of 20 ethanolic extracts from 15 medicinal plants in Sinaloa, Mexico, found that total reducing capacity strongly predicts antioxidant activity while qualitative phytochemical screening and preliminary brine shrimp toxicity do not.
Researchers optimized a choline chloride–urea deep eutectic solvent with ultrasound assistance to extract antioxidant metabolites from Cassia abbreviata leaves, finding that tailored conditions improved recovery over unoptimized NADES although methanol still extracted a broader chemical range.
Carbon chemistry research: new reactions and synthetic methods, natural products, reaction mechanisms and the handedness of molecules.
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