Researchers optimized a mild food-grade extraction that recovers 8.22 milligrams of rutin per gram from discarded Piennolo tomato leaves and showed in ex vivo porcine skin that the flavonol accumulates in the epidermis and dermis with limited transdermal passage.
A validated HPLC method has captured the first simultaneous pharmacokinetic profiles of betulinic and ursolic acids absorbed from grey mangrove extract in female Wistar rats. Mangrove extract delivers triterpenes fast in rat pharmacokinetic first Subject of Research: Pharmacokinetic profiling of…
Laboratory screening of compounds isolated from Jatropha curcas roots identified curcusones B and C as potent, slow-acting inhibitors of Plasmodium falciparum that preferentially target late-ring and early-trophozoite stages, though their selectivity over mammalian cells remains modest. News Source: Ophelia Keating.
The study, conducted by Fatemeh Abolmashadi, Mahdi Moridi Farimani, and Gholamreza Farnoosh, did not involve new laboratory experiments with the compounds themselves. Instead, the researchers reanalyzed two publicly available mouse microarray datasets, GSE150218 and GSE190056, to identify differentially expressed genes, hub genes,…
A multivariate study of 20 ethanolic extracts from 15 medicinal plants in Sinaloa, Mexico, found that total reducing capacity strongly predicts antioxidant activity while qualitative phytochemical screening and preliminary brine shrimp toxicity do not.
Researchers optimized a choline chloride–urea deep eutectic solvent with ultrasound assistance to extract antioxidant metabolites from Cassia abbreviata leaves, finding that tailored conditions improved recovery over unoptimized NADES although methanol still extracted a broader chemical range.
Tanshinones, bioactive compounds in Salvia miltiorrhiza (Chinese sage), hold significant therapeutic value, particularly in treating cardiovascular diseases. The study uncovers the molecular mechanism behind tanshinone accumulation, focusing on the role of the transcription factor SmMYB53. New Transcription Factor Found to Boost…
The escalating threat of antimicrobial resistance, coupled with the significant role of oxidative stress in chronic diseases, underscores the urgent need to identify novel multifunctional agents from natural sources to combat these issues. Clove (Syz... Uncover the latest and most…
The extraction conditions of dried Cistus incanus L. herb determine the composition and activity of the resulting extracts and therefore affect their standardization for technological use. This study evaluated the effects of solvent type (methanol, ethanol, acetone, and water), organic solvent…
A laboratory study found that water extraction of liquid-nitrogen-pretreated Cascabela thevetia leaves gave the highest yield and strongest antioxidant, antibacterial and antifungal results among six preparations.
Molecules made by plants, fungi, microbes and marine life: their discovery, structures and biosynthesis, and how chemists make them in the lab.
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