Many of the catalytic reactions that drive our modern world happen in an atomic black box. Scientists know all the components that go into a reaction, but not how they interact at an atomic level. The research was done as…
A new Frontiers in Chemistry review surveys ruthenium-catalyzed C–H activation, annulation, and hydrogen-borrowing strategies for building bioactive heterocycles. Ruthenium Catalysis Emerges as a Versatile Route to Bioactive Heterocycles
Nature (2026) Cite this article We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final…
Chemists and enzymologists have long relied on mechanism-guided design to create new enzymatic reactions, but a team writing in Nature Catalysis reports a complementary strategy: systematically screening enzyme–photocatalyst pairings to let unexpected reactivity surface on its own. Among the…
A research team at Institute of Science Tokyo has synthesized nano-sized carbon molecules in which eight helices are aligned in the same winding direction. The research team first created two helices and used their three-dimensional configuration as a clue to…
An iridium catalytic system using multiple noncovalent interactions enables para-C–H activation and borylation of free aromatic carboxylic acids without directing groups.
A dual-ligand nickel catalyst enables stereoselective synthesis of thermodynamically disfavoured cyclohexane isomers with high kinetic stereocontrol. Chemists have developed a nickel-catalysed strategy that builds thermodynamically disfavoured stereoisomers of substituted cyclohexanes, a class of ring structures central to drug discovery The…
Chemists have measured the effects of nanoconfinement in catalysis by tracking single molecules as they dive down "nanowells" and react with catalysts at the bottom. The wells in these experiments are just an average 2.3 billionths of a meter wide and…
Nature Chemical Biology (2026) Cite this article Pyruvate links glycolysis to mitochondrial oxidative metabolism, while the Warburg effect diverts it to lactate. A xenotopic chemogenetic tool based on bacterial d-alanine dehydrogenase generates pyruvate in the mitochondrial matrix independently of glycolysis, resulting…
Nature (2026) Cite this article All data supporting this work are included in the main text and its Supplementary Information files. Source data are provided with this paper. Zhang, X. et al. Regioselective hydroformylation of propene catalysed by rhodium-zeolite. Nature 629, 597–602 (2024). Yu, Z.
How chemical reactions happen: mechanisms, intermediates, radicals and reaction pathways worked out in organic and catalytic reactions.
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