Latest in Drug Delivery & Nanomedicine

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Ultrasound Unlocks Precision Drug Activation at the Molecular Level

Ultrasound offers a non-invasive and deeply penetrative means of controlling drug activation with high spatial and temporal precision. Recent advances in polymer mechanochemistry have enabled the use of ultrasound-generated mechanical forces to selectively cleave covalent and non-covalent bonds, triggering on-demand…

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Nanoparticle-delivered Pt(IV) prodrug shows boosted killing of cisplatin-tolerant oral cancer cells in 3D models

A platinum(IV) prodrug covalently attached to mesoporous silica nanoparticles showed significantly greater cytotoxicity than cisplatin in patient-derived oral squamous cell carcinoma 2D and 3D models, including cisplatin-tolerant ones. Researchers report that a novel platinum(IV) anticancer compound encapsulated in mesoporous silica nanoparticles killed…

Drug Delivery & Nanomedicine

Getting drugs where they are needed: nanoparticle and lipid carriers, polymer and hydrogel delivery systems, microneedles and controlled release.

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